Effectiveness Of Ranitidine Providing Compared With Omeprazol In Children With Gastroesofageal Reflux Disease

Abstract

Background. The drugs that are often given to children with GERD are stomach acid
suppressants, namely the H2 receptor antagonist and proton pump inhibitor (PPI) class
of drugs, but the effectiveness of the two drugs is still controversial. Objective. To
evaluate the use of PPIs and H2 RA in children with GERD through evidence-based
case studies. Methods. Systematic search for literature using the search instrument
PUBMED, Cochrane, Google Scholar, Pediatrica Indonesiana, and Sari Pediatri.
Searches included systematic review articles, randomized controlled clinical trials and
cohort studies. Abstract only studies, non-clinical evaluation results, and case reports
were excluded. Results. The study was obtained from three RCT studies comparing
the effectiveness of omeprazole and ranitidine in the treatment of GERD, all of which
have differences. Azizollahi et al demonstrated that after 2 weeks of standard doses of
omeprazole or ranitidine there was a comparable significant improvement. Ummarino
et al demonstrated that omeprazole was significantly better than high-dose ranitidine.
Cucchiara et al (1993) showed that high doses of ranitidine were as good as omeprazole.
Another study by Pfefferkorn et al showed no significant effect on the addition of
omeprazole therapy combined with ranitidine in preventing the incidence of NAB. A
study by Boccia et al comparing omeprazole, ranitidine, and non-therapy, found very
low relapse rates. Conclusion. Evidence regarding the use of ranitidine versus
omeprazole in infants and children is lacking. Based on one study specifically in the
infant age group, omeprazole and ranitidine were of comparable effectiveness. A higher
dose of ranitidine may have a better effect. In terms of complete symptom relief,
omeprazole is likely to be superior to ranitidine.