Insulinoma

Abstract

A B S T R A C T
Insulinoma is a functional neuroendocrine neoplasm consisting of insulin-producing
cells, which produce insulin uncontrollably, causing a hypoglycemic syndrome. The
Hypoglycemic syndrome is a result of hyperinsulinemia which causes adrenergic
symptoms and neuroglycopenia. The clinical diagnosis is based on the Whipple triad,
insulin, and C peptide levels in a 72-hour fasting state. Generally, insulinoma is a
benign neoplasm with a proliferation index of Ki-67 <2%. On histological features, the
growth pattern of the insulinoma is usually trabecular or solid. Some insulinomas show
a tubuloacinar growth pattern with psammoma bodies. We reported one case of
insulinoma in a 65-year-old woman, who had experienced fainting, cold sweats for 3
years, especially when the patient ate late or at midnight while sleeping. A CT scan
showed a tumor mass in the pancreas possibly an insulinoma and a pancreatectomy
was performed. The results of the histopathological examination are bu following peer
under Insulinoma.