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Abstract
A B S T R A C T
Neuroendocrine neoplasm (NEN) of gastric is a term that includes all tumour types with
neuroendocrine differentiation of gastric, well differentiated or poorly differentiated
tumour. NEN is a new term in 2019 World Health Organization (WHO) classification of
digestive system tumours. In WHO 2019 had many updates, one of them is
neuroendocrine tumours (NET) grade 3 have been included in tumour category of well
differentiated tumour or NET. Previously, NET G3 in WHO 2010 are included as poorly
differentiated tumour or neuroendocrine carcinoma (NEC). This neoplasm is genetically
well differentiated and because of that, WHO 2019 classification included them as a well
differentiated tumour. For NEC, WHO 2019 subdivided them as NEC with small cells
(SCNEC) and NEC with large cells (LCNEC). In WHO 2010, mixed type neuroendocrine
neoplasms with other components of carcinoma are called mixed adenoneuroendocrine
carcinoma (MANEC). But, not all of non-neuroendocrine components are
adenocarcinoma and it is possible that one of the components in not carcinoma. Because
of that, in WHO 2019 the term has been changed to mixed neuroendocrine-non
neuroendocrine neoplasm (MiNEN).